Synthesis, Complete Characterization, and Enantioselective Electrokinetic Separation of Functionalized Ruthenium Complex Enantiomers

Holder, Elisabeth; Trapp, Oliver; Trapp, Gabriele; Marin, Veronica; Hoogenboom, Richard; Schubert, Ulrich S.

Abstract:

Electrokinetic chromatography was employed to separate the enantiomers of two novel functionalized ruthenium(II) complexes with different polypyridyl coordination spheres. The use of anionic carboxymethyl-b-cyclodextrin as chiral mobile phase additive resulted in maximum efficiency and resolution for the enantiomer separation of both transition metal complexes. The syntheses of the [4-(3-hydroxypropyl)- 4'-methyl-2,2'-bipyridine]-bis(2,2'-bipyridine)ruthenium(II)-bis(tetrafluoroborate) and [4- (3-hydroxypropyl)-4'-methyl-2,2'-bipyridine]-bis(4,4'-dimethyl-2,2'-bipyridine)ruthenium (II)-bis(tetrafluoroborate) complexes and their complete characterization by means of two-dimensional 1H and 13C{1H} NMR techniques (1H–1H COSY and 1H–13C HMQC) as well as elemental analyses and MALDI-TOFMS are described in detail. The functionalized complexes can be used as building blocks for further reactions with polymers, biopolymers, surfaces and nanoparticles.

Year:

2004

Type of Publication:

Article

Journal:

Chirality

Volume:

16

Pages:

363 - 368