Sample Target Substrates with Reduced Spot Size for MALDI-TOF Mass Spectrometry Based on Patterned Self-Assembled Monolayers

Herzer, Nicole; Eckardt, Rebecca; Höppener, Stephanie; Schubert, Ulrich S.

Abstract:

The wetting properties of structured self-assembled monolayers are used to fabricate sample target substrates for MALDI-TOF mass spectrometry. Combining the advantages of a hydrophobic-hydrophilic surface pattern and the possibility of obtaining micrometer patterns allows an increase in the sensitivity of MALDI-TOF mass spectrometry analysis and a reduction in the traceable concentration down to fmol mL-1. This easy, cheap and fast patterning process provides substrates that allow sensitive, high-resolution mass spectrometry of dilute solutions.

Year:

2009

Type of Publication:

Article

Journal:

Advanced Functional Materials

Volume:

19

Pages:

2777 - 2781