Click Chemistry beyond Metal-Catalyzed Cycloaddition

Becer, C. Remzi; Hoogenboom, Richard; Schubert, Ulrich S.

Abstract:

The overwhelming success of click chemistry encouraged researchers to develop alternative “spring-loaded” chemical reactions for use in different fields of chemistry. Initially, the copper(I)-catalyzed azidealkyne cycloaddition was the only click reaction. In recent years, metal-free [3+2] cycloaddition reactions, Diels–Alder reactions, and thiol-alkene radical addition reactions have come to the fore as click reactions because of their simple synthetic procedures and high yields. Furthermore, these metal-free reactions have wide applicability and are physiologically compatible. These and other alternative click reactions expand the opportunities for synthesizing small organic compounds as well as tailor-made macromolecules and bioconjugates. This Minireview discusses the success and applicability of new, in particular metal-free, click reactions.

Year:

2009

Type of Publication:

Article

Journal:

Angewandte Chemie

Volume:

48

Pages:

2 - 11