Synthesis , Characterization, and Antitumor Activity of Pt(II) Complexes with Sugar Conjugated Triazole Ligands

Yano, Shigenobu; Ohi, Hiromi; Ashizaki, Mizue; Obata, Makoto; Mikata, Yuji; Tanaka, Rika; Nishioka, Takanori; Kinoshita, Isamu; Sugai, Yuko; Okura, Ichiro; Ogura, Shun-ichiro; Czaplewska, Justyna; Gottschaldt, Michael; Schubert, Ulrich S.; Funabiki, Takuzo; Morimoto, Keiko; Nakai, Misaki

Abstract:

Four platinum(II) and palladium(II) complexes with sugar-conjugated bipyridine-type triazole ligands, [PtIICl2(AcGlc-pyta)] (3), [PdIICl2(AcGlc-pyta)] (4), [PtIICl2(Glc-pyta)] (5), and [PdIICl2(Glc-pyta)] (6), were prepared and characterized by mass spectrometry, elemental analysis, 1H- and 13C-NMR, IR as well as UV/VIS spectroscopy, where AcGlc-pyta and Glc-pyta denote 2-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]ethyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (1) and 2-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]ethyl β-D-glucopyranoside (2), respectively. The solid-state structure of complex 6 was determined by single-crystal X-ray-diffraction analysis. These complexes exhibited in vitro cytotoxicity against human cervix tumor cells (HeLa) though weaker than that of cisplatin.

Year:

2012

Type of Publication:

Article

Keywords:

Sugars; Platinum complexes; Palladium complexes; Click chemistry; Cytotoxic activity; X Ray crystallography

Journal:

Chemistry {&} Biodiversity

Volume:

9

Pages:

1903 - 1915