Biological Evaluation of 1,2,3-Triazole based Polymers for Potential Applications as Hard Tissue Material

Pretzel, David; Sandmann, Benedict; Hartlieb, Matthias; J\", ; urgen Vitz, ; Hölzer, Stefan; Fritz, Nicole; Moszner, Norbert; Schubert, Ulrich S.

Abstract:

This contribution deals with the synthesis and subsequent bulk polymerization of multifunctional electron-deficient internal alkynes with several multifunctional azides in a metal-free 1,3-dipolar azide–alkyne cycloaddition. The biocompatibility of alkynes, azides, and resulting networks was investigated in a cell biological study. All monomers revealed distinctive concentration-dependent cytotoxic properties. These harmful side effects on the cell integrity were completely diminished after polymerization of the educts resulting in materials with highly biocompatible properties.

Year:

2015

Type of Publication:

Article

Journal:

Journal of Polymer Science: Part A: Polymer Chemistry

Volume:

53

Pages:

1843 - 1847