Abundance correction for mass discrimination effects in polymer mass spectra

Engler, Martin S.; Crotty, Sarah; Barthel, Markus J.; Pietsch, Christian; Schubert, Ulrich S.; Böcker, Sebastian

Abstract:

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) is frequently used to analyze homo- and copolymers, i.e. for computing copolymer fingerprints. However, the oligomer abundances are influenced by mass discrimination, i.e. mass- and composition-dependent ionization. We have developed a computational method to correct the abundance bias caused by the mass discrimination.

Research areas:

• Mass Spectrometry

Year:

2016

Type of Publication:

Article

Journal:

Rapid Communications in Mass Spectrometry

Volume:

30

Pages:

1233 - 1241

DOI:

10.1002/rcm.7553