Polymer Science
Members
Alam, Shahidul; Alex, Julien; Bandelli, Damiano; Brendel, Johannes C.; Czaplewska, Justyna; Dirauf, Michael; Elbert, Johannes; Engel, Nora; Englert, Christoph; Festag, Grit; Fluhr, Daniel; Gangapurwala, Gauri; Gottschaldt, Michael; Grätzel, Michael; Gruschwitz, Franka; Sanchez, Carlos Guerrero; Hausig, Franziska; Hoppe, Harald; Johne, Christopher; Klein, Tobias; Kleinsteuber, Maximilian; Klemm, Paul; Kötteritzsch, Julia; Kuhl, Natascha; Leiske, Meike; Majdanski, Tobias; Meier, Alexander; Muljajew, Irina; Öttking, Rolf; Paulus, Renzo M.; Pröhl, Michael; Reifarth, Martin; Sahn, Martin; Seupel, Susanne; Sobotta, Fabian; Stobbe, Julian; Trützschler, Anne-Kristin; Tymen, Simon; Ulbrich, Jens; Vitz, Jürgen; Vollrath, Antje; Weber, Christine; Wei, Peng; Wloka, Thomas; Workneh, Getachew Adam; Yildirim, Ilknur; Yildirim, Turgay; Zhang, Junliang
Description
Combinational techniques, parallel experimentation and high-throughput methods represent a very promising approach in order to speed up the preparation and investigation of new polymeric materials: a large variety of parameters can be screened simultaneously resulting in new structure/property relationships. The field of polymer research seems to be perfectly suited for parallel and combinatorial methods due to the fact that many parameters can be varied during synthesis, processing, blending as well as compounding. In addition, numerous important parameters have to be investigated, such as molecular weight, polydispersity, viscosity, hardness, stiffness and other application specific properties. A number of corresponding high throughput techniques have been developed in the last few years and their introduction into the commercial market further boosted the development. These combinatorial approaches can reduce the time to market for new polymeric materials drastically compared to traditional approaches and allow a much more detailed understanding of polymers from the macroscopic to the nanoscopic scale. Here we provide an overview of the present status of combinatorial and parallel polymer synthesis and high throughput screening. |
Ciamician (1857-1922) tested hundreds of samples in parallel on the roof of his laboratory at the University of Bologna. (Photo courtesy of the University of Bologna). |
Appearance of the reaction vessels of polymerization of 2-ethyl-2-oxazoline at varying temperatures. The colorless vessels were polymerized at low temperatures and the orange vessels were polymerized at high temperatures. |
Publications
- Chemo-Enzymatic PEGylation/POxylation of Murine Interleukin‑4
- Platinum‐terpyridine complexes in polymers: A novel approach for the synthesis of self‐healing metallopolymers
- Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications
- Maintaining the Hydrophilic–Hydrophobic Balance of Polyesters with Adjustable Crystallinity for Tailor-Made Nanoparticles
- Accelerating the acidic degradation of a novel thermoresponsive polymer by host–guest interaction
- One‐Pot Synthesis of Block Copolymers by a Combination of Living Cationic and Controlled Radical Polymerization
- TBD‐Catalyzed Ring‐Opening Polymerization of Alkyl‐Substituted Morpholine‐2,5‐Dione Derivatives
- Flexible Thermoelectric Polymer Composites Based on a Carbon Nanotubes Forest
- A translation of the structure of mussel byssal threads into synthetic materials by the utilization of histidine-rich block copolymers
- The Power of Shielding: Low Toxicity and High Transfection Performance of Cationic Graft Copolymers Containing Poly(2-oxazoline) Side Chains
- PMMA-g-OEtOx Graft Copolymers: Influence of Grafting Degree and Side Chain Length on the Conformation in Aqueous Solution
- Urethanes as reversible covalent moieties in self-healing polymers
- Conjugated Oligomers as Fluorescence Marker for the Determination of the Self-Healing Efficiency in Mussel-Inspired Polymers
- Accelerating the acidic degradation of a novel thermoresponsive polymer by host–guest interaction
- Comparison of random and gradient amino functionalized poly(2‐oxazoline)s: Can the transfection efficiency be tuned by the macromolecular structure?
- Tumor targeting with pH-responsive poly(2-oxazoline)-based nanogels for metronomic doxorubicin treatment
- Influence of Aspartate Moieties on the Self‐Healing Behavior of Histidine‐Rich Supramolecular Polymers
- Do YouGet What YouSee?Understanding Molecular Self-Healing
- Spherical and Worm‐Like Micelles from Fructose‐Functionalized Polyether Block Copolymers
- How to Design a Self‐Healing Polymer: General Concepts of Dynamic Covalent Bonds and Their Application for Intrinsic Healable Materials
- Temperature-Tuning of Optical Properties and Molecular Aggregation in AnE-PVstat Copolymer Solution
- LCST behavior of poly(2-ethyl-2-oxazoline) containing diblock and triblock copolymers
- Oxidation-responsive micelles by a one-pot polymerization-induced self-assembly approach
- How To Tune the Gene Delivery and Biocompatibility of Poly(2-(4-aminobutyl)-2-oxazoline) by Self- and Coassembly
- Old meets new: Combination of PLA and RDRP to obtain sophisticated macromolecular architectures
- Remendable polymers via reversible Diels–Alder cycloaddition of anthracene‐containing copolymers with fullerenes
- The influence of the grafting density of glycopolymers on the lectin binding affinity of block copolymer micelles
- Retinol initiated poly(lactide)s: stability upon polymerization and nanoparticle preparation
- Thermosensitive spontaneous gradient copolymers with block- and gradient-like features
- Synthetic approaches towards structurally-defined electrochemically and (photo)redox-active polymer architectures
- Effect of the Degree of Quaternization and Molar Mass on the Cloud Point of Poly[2-(dimethylamino)ethyl methacrylate] Aqueous Solutions: A Systematic Investigation
- Exploring the Limits of the Geometric Copolymerization Model
- Tailoring Cellular Uptake and Fluorescence of Poly(2-oxazoline)-Based Nanogels
- Poly(N-alkyl-3,6-carbazole)s via Suzuki–Miyaura Polymerization: From Macrocyclization toward End Functionalization
- Thermoresponsive polymers with lower critical solution temperature: from fundamental aspects and measuring techniques to recommended turbidimetry conditions
- Dual pH and ultrasound responsive nanoparticles with pH triggered surface charge-conversional properties
- One-pot synthesis of electro-active polymer gels via Cu(0)-mediated radical polymerization and click chemistry
- Increased stability in self-healing polymer networks based on reversible Michael addition reactions
- Optimized Photoinitiator for Fast Two-Photon Absorption Polymerization of Polyester-Macromers for Tissue Engineering
- Polymeric Halogen-Bond-Based Donor Systems Showing Self-Healing Behavior in Thin Films
- Hydrophilic Poly(naphthalene diimide)-Based Acceptor–Photosensitizer Dyads: Toward Water-Processible Modular Photoredox-Active Architectures
- RAFT polymerization and thio-bromo substitution: An efficient way towards well-defined glycopolymers
- d-Fructose-Decorated Poly(ethylene imine) for Human Breast Cancer Cell Targeting
- 3rd Generation Poly(ethylene imine)s for Gene Delivery
- Histidine–Zinc Interactions Investigated by Isothermal Titration Calorimetry (ITC) and their Application in Self-Healing Polymers
- An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo
- Bi-diketopyrrolopyrrole (Bi-DPP) as a novel electron accepting compound in low band gap π-conjugated donor–acceptor copolymers/oligomers
- Synthesis and in vitro Toxicity of D -Glucose and D -Fructose Conjugated Curcumin–Ruthenium Complexes
- Specific Surface versus Electrochemically Active Area of the Carbon/Polypyrrole Capacitor: Correlation of Ion Dynamics Studied by an Electrochemical Quartz Crystal Microbalance with BET Surface
- Polymerization of ethylene oxide under controlled monomer addition via a mass flow controller for tailor made polyethylene oxides
- Dual Responsive Nanoparticles from a RAFT Copolymer Library for the Controlled Delivery of Doxorubicin
- Synthesis and characterization of colored EUDRAGIT® as enteric coating material
- Immobilized glycopolymers: Synthesis, methods and applications
- Poly(DCAQI): Synthesis and characterization of a new redox-active polymer
- Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release
- Self-Healing Polymers Based on Reversible Covalent Bonds
- Microwave-Assisted Cationic Ring-Opening Polymerization of 2-Oxazolines
- Selective Uptake of a Fructose Glycopolymer Prepared by RAFT Polymerization into Human Breast Cancer Cells
- Preparation of Non-spherical Particles from Amphiphilic Block Copolymers