Integration of MALDI-TOFMS as high-throughput screening tool into the workflow of combinatorial polymer research

Meier, Michael; Schubert, Ulrich S.

Abstract:

The possibilities of integration of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) as high-throughput screening tool into the workflow of combinatorial materials research are discussed. A multiple layer sample prepn. technique for MALDI is described in detail and its possibilities of automation and miniaturization are discussed. Automated MALDI sample prepn. could be performed within an automated synthesizer robot and with an ink-jet printer. The first approach offers the possibility of online reaction monitoring, whereas the second approach gives the opportunity of applications in ultra-high-throughput environments. An example of high-throughput screening of a polymn. reaction by MALDI-TOFMS is discussed. [on SciFinder (R)]

Year:

2005

Type of Publication:

Article

Journal:

Review of Scientific Instruments

Volume:

76

Number:

6

Pages:

06221/1 - 06221/5