Automated Multiple-layer Spotting for MALDI-TOFMS of Synthetic Polymers utilizing Ink-jet Printing Technology

Meier, Michael; de Gans, Berend-Jan; van den Berg, Antje M. J.; Schubert, Ulrich S.

Abstract:

Recently, a new multiple-layer matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) sample spotting technique for poly(ethylene glycol), offering improved analysis possibilities, was described. In this contribution the application of ink-jet printing to automated, multiple-layer MALDI-TOFMS sample preparation of synthetic polymers is presented, allowing accurate deposition of matrix, additive and analyte solutions. The new sample preparation technique was evaluated for poly(ethylene glycol) as well as poly(methyl methacrylate) standards, and optimized settings for both synthetic polymers have been obtained.

Year:

2003

Type of Publication:

Article

Journal:

Rapid Communications in Mass Spectrometry

Volume:

17

Pages:

2349 – 2353