Sample Target Substrates with Reduced Spot Size for MALDI-TOF Mass Spectrometry Based on Patterned Self-Assembled Monolayers
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Herzer, Nicole; Eckardt, Rebecca; Höppener, Stephanie; Schubert, Ulrich S.
- Abstract:
- The wetting properties of structured self-assembled monolayers are used to
fabricate sample target substrates for MALDI-TOF mass spectrometry.
Combining the advantages of a hydrophobic-hydrophilic surface pattern and
the possibility of obtaining micrometer patterns allows an increase in the
sensitivity of MALDI-TOF mass spectrometry analysis and a reduction in the
traceable concentration down to fmol mL-1. This easy, cheap and fast
patterning process provides substrates that allow sensitive, high-resolution
mass spectrometry of dilute solutions.
- Year:
- 2009
- Type of Publication:
- Article
- Journal:
- Advanced Functional Materials
- Volume:
- 19
- Pages:
- 2777 - 2781