Click Chemistry beyond Metal-Catalyzed Cycloaddition
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Becer, C. Remzi; Hoogenboom, Richard; Schubert, Ulrich S.
- Abstract:
- The overwhelming success of click chemistry encouraged researchers
to develop alternative “spring-loaded” chemical reactions for use in
different fields of chemistry. Initially, the copper(I)-catalyzed azidealkyne
cycloaddition was the only click reaction. In recent years,
metal-free [3+2] cycloaddition reactions, Diels–Alder reactions, and
thiol-alkene radical addition reactions have come to the fore as click
reactions because of their simple synthetic procedures and high yields.
Furthermore, these metal-free reactions have wide applicability and
are physiologically compatible. These and other alternative click
reactions expand the opportunities for synthesizing small organic
compounds as well as tailor-made macromolecules and bioconjugates.
This Minireview discusses the success and applicability of new, in
particular metal-free, click reactions.
- Year:
- 2009
- Type of Publication:
- Article
- Journal:
- Angewandte Chemie
- Volume:
- 48
- Pages:
- 2 - 11