Sugar-Selective Enrichment of a d-Glucose-Substituted Ruthenium Bipyridyl Complex Inside HepG2 Cancer Cells

Gottschaldt, Michael; Schubert, Ulrich S.; Rau, Sven; Yano, Shigenobu; Vos, Johannes G.; Kroll, Torsten; Clement, Joachim; Hilger, Ingrid

Abstract:

Ruthenium bipyridyl (bpy) complexes display luminescent properties and a rich photochemistry associated with the visible- light-induced formation of a long-lived 3MLCT state (t up to 1 ms), which can be efficiently quenched by oxygen under the formation of singlet oxygen (F=0.86).These properties render the complexes interesting candidates for fluorescent sensors and photodynamic-therapy applications.However, the in vivo potential of these complexes depends heavily upon both the molecular (sensor applications) and the cellular (photodynamic therapy applications) recognition of the luminescent probes. In addition, Ru(bpy)3 2+-type complexes are positively charged ions and therefore possess only limited cellmembrane permeability for intact cells; this significantly limits their potential applications.

Year:

2010

Type of Publication:

Article

Journal:

ChemBioChem

Volume:

11

Pages:

649 - 652