High-throughput experimentation applied to atom transfer radical polymerization: Automated optimization of the copper catalysts removal from polymers
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Zhang, Huiqi; Abeln, Caroline H.; Fijten, Martin W. M.; Schubert, Ulrich S.
- Abstract:
- Combinatorial chemistry and high-throughput experimentation have
drawn great attention in recent years because of their significant advantages in
increasing the research productivity. One of the emerging fields is their application
in polymer science. Herein we describe the high-throughput optimization of
purification conditions for polymers prepared via atom transfer radical
polymerization using an automated synthesizer. The effects of the column
materials, column lengths and eluent volumes on the purification efficiency as well
as the molecular weights of the obtained purified polymers were systematically
investigated for the first time. The optimum purification conditions for the removal
of copper catalysts are provided. As a result an online high-throughput purification
workflow using SPE cartridges is now available for the utilization in automated
parallel synthesizers for ATRP screening experiment.
- Year:
- 2006
- Type of Publication:
- Article
- Journal:
- e-Polymers
- Number:
- 8
- Pages:
- 1 - 9