Protocol for Automated Kinetic Investigation/Optimization of the RAFT Polymerization of Various Monomers
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Becer, C. Remzi; Groth, Andrew M.; Hoogenboom, Richard; Paulus, Renzo M.; Schubert, Ulrich S.
- Abstract:
- A standard protocol for the parallel optimization of Reversible Addition – Fragmentation
Chain Transfer (RAFT)polymerization conditions using an automated synthesizer is described
in this report. Experimental design based on the knowledge obtained from
previous screening experiments and the literature is the most effective initial step of the
High-Throughput Experimentation (HTE)cy cle. In this paper, the polymerization
procedure is explained step-by-step including preparation of stock solutions, inertization
of the reactors and synthesizer environment, liquid transfers to or from the reactor vessels
including sampling, as well as termination of the polymerization. Automated characterization
techniques for the determination of monomer conversion and the molecular weight
distribution of the polymers are discussed to complete the HTE cycle. Consequently,
analysis of the data obtained from parallel screening of reactions and their products will
result in the design of the next experimental cycle.
- Year:
- 2008
- Type of Publication:
- Article
- Journal:
- QSAR {&} Combinatorial Science
- Volume:
- 8
- Pages:
- 977 - 983