High-Throughput Synthesis and Screening of a Library of Random and Gradient Copoly(2-oxazoline)s

Hoogenboom, Richard; Fijten, Martin W. M.; Wijnans, Sanne; van den Berg, Antje M. J.; Thijs, Hanneke M. L.; Schubert, Ulrich S.

Abstract:

The living cationic ring opening polymerization of 2-oxazolines was discovered in 1966. After this discovery, the resulting biocompatible poly(2-oxazoline)s have been used for a wide variety of applications.Moreover, amphiphilic structures are easily accessible by the sequential polymerization of a hydrophilic monomer (e.g., 2-methyl- or 2-ethyl-2-oxazoline) and a hydrophobic monomer (e.g., 2-nonyl- or 2-phenyl-2- oxazoline). Unlike block copoly(2-oxazoline)s, random copoly( 2-oxazoline)s have not been extensively investigated so far. The possibility of copolymerizing different 2-oxazolines has been demonstrated by several groups; however, reactivity ratios have only been determined for copolymerizations involving 2-phenyl-2-oxazoline (PhOx). Due to the low reactivity of PhOx, the copolymerizations resulted in blocky structures instead of random or gradient copolymers. Moreover, the properties of copoly(2-oxazoline)s have not been studied in detail.

Year:

2006

Type of Publication:

Article

Journal:

Journal of Combinatorial Chemistry

Volume:

8

Pages:

145 - 148