The Introduction of High-Throughput Experimentation W Methods for Suzuki–Miyaura Coupling Reactions in University Education

Hoogenboom, Richard; Meier, Michael; Schubert, Ulrich S.

Abstract:

During the last decade, combinatorial and high-throughput techniques have revolutionized pharmaceutical research. Hundreds to thousands of times more compounds can be synthesized and screened than with traditional approaches. This can, in principle, decrease the time-to-market for new drugs tremendously. Moreover, combinatorial and high-throughput techniques are increasingly being applied in fields such as inorganic materials catalysis, and polymer science. Although these activities are significantly expanding within companies, high-throughput experimentation (HTE) is not (yet) an important issue in academic chemical research, even though students will most likely use those techniques after their education. Therefore, we have initiated small research projects for second-year students that include the use of fully automated synthesis robots. In those projects they learn and discover the new way of thinking that is required for combinatorial and highthroughput research.

Year:

2005

Type of Publication:

Article

Journal:

Journal of Chemical Education

Volume:

82

Number:

11

Pages:

1693 - 1696