Automated Parallel Investigations/Optimizations of the Reversible Addition-Fragmentation Chain Transfer Polymerization of Methyl Methacrylate
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Fijten, Martin W. M.; Meier, Michael; Hoogenboom, Richard; Schubert, Ulrich S.
- Abstract:
- Poly(methyl methacrylate)s were successfully synthesized in a controlled
fashion via reversible addition-fragmentation chain transfer polymerizations utilizing
an automated synthesizer. Sixteen polymers were synthesized in a parallel way utilizing
the Chemspeed AcceleratorTM SLT100 to investigate the reproducibility and the
control over the polymerizations. The obtained polymers were characterized by gel
permeation chromatography (GPC) and automated MALDI TOFMS measurements,
thereby proving the reproducibility and controllability of the investigated automated
setup. Furthermore, temperature optimization reactions were performed utilizing an
individually heatable reactor block. Moreover, to demonstrate the presence of active
polymer chains in the reaction mixture, chain extension polymerizations were performed
on the automated synthesizer. The results obtained from these chain extension
experiments demonstrate the possibility to design well-defined A-b-B block copolymers
with different monomers as building units.
- Year:
- 2004
- Type of Publication:
- Article
- Keywords:
- reversible addition-fragmentation chain transfer polymerization; methyl methacrylate; combinatorial material research; high-throughput experimentation; automated MALDI TOFMS spotting; parallel chemistry
- Journal:
- Journal of Polymer Science: Part A: Polymer Chemistry
- Volume:
- 42
- Pages:
- 5775 - 5783