Hydrodynamic properties of cyclodextrin molecules in dilute solutions

Pavlov, George M.; Korneeva, Evguenia V.; Smolina, Natalia A.; Schubert, Ulrich S.

Abstract:

Three well-known representatives of the cyclodextrin family were completely characterized by molecular hydrodynamics methods in three different solvents. For the first time the possibility of an estimation of velocity sedimentation coefficients s between 0.15 and 0.5 S by the numerical solution of the Lamm equation is shown. Comparison of the experimental hydrodynamic characteristics of the cyclodextrins with theoretical calculations for toroidal molecules allows an estimation of the thickness of the solvent layers on the surface of cyclodextrin molecules.

Year:

2010

Type of Publication:

Article

Journal:

European Biophysics Journal

Volume:

39

Pages:

371 - 379