Multifunctional Poly(2-oxazoline) Nanoparticles for Biological Applications

Kempe, Kristian; Vollrath, Antje; Schaefer, Hendrik W.; Pöhlmann, Tobias; Biskup, Christoph; Hoogenboom, Richard; Hornig, Stephanie; Schubert, Ulrich S.

Abstract:

New multifunctional copoly(2-oxazoline) nanoparticles were prepared for cell studies. The polymer contains double-bond side chains as potential reaction sites for ‘‘thio’’-click reactions as well as a fluorescein label covalently bound to the polymer backbone. Using the nanoprecipitation technique, spherical nanoparticles of 200–800nm were obtained. Confocal laser scanning microscopy measurements revealed the cellular uptake of the nanoparticles.

Year:

2010

Type of Publication:

Article

Journal:

Macromolecular Rapid Communications

Volume:

31

Pages:

1869 - 1873