InIII and GaIII Complexes of Sugar-Substituted Tripodal Trisalicylidene Imines: The First 68Ga-Labelled Sugar Derivative

Gottschaldt, Michael; Bohlender, Carmen; Pospiech, Anne; Goerls, Helmar; Walther, Martin; Mueller, Dirk; Klette, Ingo; Baum, Richard P.; Schubert, Ulrich S.

Abstract:

Gallium and indium complexes derived from salicylaldimines of 1,1,1-tris(aminomethyl)ethane (TAME) with pendant xylose, glucose and galactose units have been synthesised as model compounds for potential application as radiotracers. The formed neutral complexes have been characterised by NMR spectroscopy, elemental analysis, mass spectrometry and, in the case of the galactose-bearing InIII complex, by single-crystal X-ray structure analysis. Octahedral coordination was observed with the appearance of an equilibrium of Λ- and Δ-isomers at the metal centre. The glucose-appended ligand was radiolabelled with 68GaIII ions in up to 98% yield depending on the prevailing pH value. The in vitro stability of the radioactive complex was examined by challenge experiments against apo-transferrin and blood plasma. Very high stability was observed; even after a period of 2 h, 90% of the complex could still be detected.

Year:

2009

Type of Publication:

Article

Journal:

European Journal of Inorganic Chemistry

Volume:

-

Pages:

4298 - 4307