Characterization of Different Poly(2-oxazoline) Block Copolymers by MALDI-TOF MS/MS and ESI-Q-TOF MS/MS
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Baumgärtel, Anja; Altuntas, Esra; Kempe, Kristian; Crecelius, Anna; Schubert, Ulrich S.
- Abstract:
- A complete library of poly(2-oxazoline) block
copolymers was synthesized via cationic ring opening polymerization
for the characterization by two different soft ionization
techniques, namely matrix-assisted laser desorption/
ionization time-of-flight mass spectrometry (MALDI-TOF MS)
and electrospray ionization quadrupole time-of-flight mass
spectrometry (ESI-Q-TOF MS). In addition, a detailed characterization
was performed by tandem MS to gain more structural
information about the block copolymer composition and its
fragmentation behavior. The fragmentation of the poly(2-oxazoline)
block copolymers revealed the desired polymer structure
and possible side reactions, which could be explained by
different mechanisms, like 1,4-ethylene or hydrogen elimination
and the McLafferty þ1 rearrangement. Polymers with aryl
side groups showed less fragmentation due to their higher stability
compared to polymers with alkyl side groups. These
insights represent a further step toward the construction of a
library with fragments and their fragmentation pathways for
synthetic polymers, following the successful examples in proteomics.
- Year:
- 2010
- Type of Publication:
- Article
- Journal:
- Journal of Polymer Science: Part A: Polymer Chemistry
- Volume:
- 48
- Pages:
- 5533 - 5540