Labeled Nanoparticles Based on Pharmaceutical EUDRAGIT S 100 Polymers
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Vollrath, Antje; Schubert, Stephanie; Windhab, Norbert; Biskup, Christoph; Schubert, Ulrich S.
- Abstract:
- The pharmaceutically important polymer P(MAA–r–MMA)1:2 (EUDRAGIT1 S100) was investigated
concerning its behavior to form nanoparticles via nanoprecipitation. The particles
obtained were characterized regarding their size, shape, and characteristics using DLS, SEM,
and AUC. Furthermore, the P(MAA–r–MMA)1:2 copolymer was modified with different markers
in order to achieve polymer-based nanocarrier systems, which are detectable and may be
useful for controlled drug delivery devices to monitor the drug pathways. The particles were
labeled by physical entrapment as well as by covalent attachment of various markers, e.g.,
radicals, fluorescent-, and near-infrared dyes, to the polymer. Physical entrapment of radicals
into the polymeric units was performed by co-nanoprecipitation of P(MAA–r–MMA)1:2 and a
radical marker. By means of covalent binding of the markers to the polymer, a stable and more
defined labeling of the particles was also performed, leading only to a low degree of
modification of the pharmaceutical polymer. After nanoprecipitation,
the resulting labeled particles were characterized
by SEM and DLS, whereas their biocompatibility
was proven by in vitro studies. In order to ensure the
possibility of detection of the particles inside the body for
drug delivery-, sensor-, and imaging applications, the
polymeric carriers were also investigated by electron
spin resonance, fluorescence, as well as near-infrared
spectroscopy.
- Year:
- 2010
- Type of Publication:
- Article
- Journal:
- Macromolecular Rapid Communications
- Volume:
- 31
- Pages:
- 2053 - 2058