Prospects of Metal Complexes Peripherally Substituted with Sugars in Biomedicinal Applications
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Gottschaldt, Michael; Schubert, Ulrich S.
- Abstract:
- Metal complexes possess unique tunable
properties, such as radioactivity, cytotoxicity or photophysical
features, enabling them to act as diagnostic
tracers or therapeutic agents. In applying them in biological
systems, it is often necessary to enhance their
solubility and biocompatibility. To achieve such goals,
like the targeting of binding domains, transport systems
and enzyme activities, the attachment of carbohydrate
moieties appears to be suitable. Sugar-substitution in
the periphery of metal complexes has therefore become
a strongly growing field of research. Outlined herein is
a selection of recent examples.
- Year:
- 2009
- Type of Publication:
- Article
- Journal:
- Chemistry - A European Journal
- Volume:
- 15
- Pages:
- 1548 – 1557