Examination and optimization of the self-assembly of biocompatible, polymeric nanoparticles by high-throughput nanoprecipitation
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Perevyazko, Igor; Delaney, Joseph T.; Vollrath, Antje; Pavlov, George M.; Schubert, Stephanie; Schubert, Ulrich S.
- Abstract:
- In recent years, the development of polymer nanoparticle suspensions by nanoprecipitation has gained
increased attention both by industry and academia. However, the process by which such formulations
are prepared is a highly empirically driven enterprise, whereby developing optimized formulations
remains an iterative process. In this contribution, a new approach towards exploration of the materials
space for these systems is reported, based on systematically varying processing and formulation to
understand their influence on the characteristics of the resulting materials. Taking advantage of the
tools and techniques that have already been standardized by informatics-driven life sciences disciplines,
we have prepared libraries of nanoparticle formulations of poly(methyl methacrylate-stat-acrylate),
poly(lactic-co-glycolic acid), and acetal-derivatized dextran by using a pipetting robot. They were
subsequently characterized using a dynamic light scattering plate reader, analytical ultracentrifugation,
and scanning electron microscopy. With this high-throughput nanoprecipitation approach, large
numbers of materials can be prepared, screened, and the formulation rationally optimized.
- Year:
- 2011
- Type of Publication:
- Article
- Journal:
- Soft Matter
- Volume:
- 7
- Pages:
- 5030 - 5035