Organ Weaving - A New Strategy for Artificial Organ Development
-
Liberski, Albert R.; Delaney, Joseph T.; Schaefer, Hendrik W.; Perelaer, Jolke; Schubert, Ulrich S.
- Abstract:
- The concept of ‘‘organ weaving’’ is presented, a fabrication technique that can be an attractive
option for the development of artificial tissues and organs. ‘‘Living threads’’ are created by
immersing threads that are soaked in a CaCl2 solution into a sodium-alginate-loaded cell
suspension bath, encapsulating the cells and creating a bio-friendly, easily manageable
starting material for building up larger scaffold
structures. Such living threads have the
advantage of being a particularly mild culturing
medium for mammalian cells, protecting the cells
during subsequent processing steps from dehydration
and other rapid changes in the chemistry
of the surrounding environment. Connecting
different types of threads into 3D objects gives
unique opportunities to address tissue engineering
challenges.
- Year:
- 2011
- Type of Publication:
- Article
- Journal:
- Macromolecular Bioscience
- Volume:
- 11
- Pages:
- 1491-1498