Synthesis of a glycopolymeric PtII carrier and its induction of apoptosis in resistant cancer cells

Wild, Andreas; Babiuch, Krzysztof; König, Marcel; Winter, Andreas; Hager, Martin D.; Gottschaldt, Michael; Prokop, Aram; Schubert, Ulrich S.

Abstract:

Post-polymerization modification of a poly(pentafluorostyryl) backbone with β-D-galactose and a terpyridine platinum complex yields a well-defined material that represents the first example of a metal-conjugated glycopolymer. It reveals anti-proliferative activity, no detectable necrotic cytotoxicity, and efficiently induces apoptosis in both wild-type as well as resistant Nalm-6 leukemia cell lines.

Year:

2012

Type of Publication:

Article

Journal:

Chemical Communications

Pages:

DOI: 10.1039/C2CC312