Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release

Rietscher, René; Czaplewska, Justyna; Majdanski, Tobias; Gottschaldt, Michael; Schubert, Ulrich S.; Schneider, Marc; Lehr, Claus-Michael

Abstract:

The effect of modifying the well-established pharmaceutical polymer PLGA by different PEG-containing block-copolymers on the preparation of ovalbumin (OVA) loaded PLGA nanoparticles (NPs) was studied. The used polymers contained poly(d,l-lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG) and poly(allyl glycidyl ether) (PAGE) as building blocks. The double emulsion technique yielded spherical NPs in the size range from 170 to 220 nm (PDI e targeting introducing a reactive group, led to a significantly higher loading (+25%) and release rate (+100%), compared to PLGA and PEG-b-PLGA NPs.

Research areas:

• Polymer Science

Year:

2016

Type of Publication:

Article

Journal:

International Journal of Pharmaceutics

Volume:

500

Pages:

187 - 195

DOI:

10.1016/j.ijpharm.2016.01.021