Cellular uptake of PLA nanoparticles studied by light and electron microscopy: synthesis, characterization and biocompatibility studies using an iridium(III) complex as correlative label
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Reifarth, Martin; Pretzel, David; Schubert, Stephanie; Weber, Christine; Heintzmann, Rainer; Höppener, Stephanie; Schubert, Ulrich S.
- Abstract:
- We present the synthesis of polylactide by ring-opening polymerization using a luminescent iridium(III) complex acting as initiator. The polymer was formulated into nanoparticles, which were taken up by HEK-293 cells. We could show that the particles provided an appropriate contrast in both superresolution fluorescence and electron microscopy, and, moreover, are non-toxic, in contrast to the free iridium complex.
- Research areas:
- Year:
- 2016
- Type of Publication:
- Article
- Journal:
- Chemical Communications
- Volume:
- 52
- Pages:
- 4361 - 4364
- DOI:
- 10.1039/C5CC09884J