An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo
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Sun, Wen; Li, Shuyi; Häupler, Bernhard; Liu, Juan; Jin, Shubin; Steffen, Werner; Schubert, Ulrich S.; Butt, Hans-Jürgen; Liang, Xingjie; Wu, Si
- Abstract:
- An amphiphilic Ru-containing block copolymer is used as a photoactivated polymetallodrug for anticancer phototherapy. The block copolymer self-assembles into nanoparticles, which can accumulate at tumor sites in a mouse model. Red light irradiation of the block copolymer nanoparticles releases anticancer Ru complexes and generates cytotoxic 1O2, both of which can inhibit tumor growth.
- Research areas:
- Year:
- 2017
- Type of Publication:
- Article
- Journal:
- Advanced Materials
- Volume:
- -
- Number:
- in Press
- DOI:
- 10.1002/adma.201603702