Spherical and Worm‐Like Micelles from Fructose‐Functionalized Polyether Block Copolymers

Majdanski, Tobias C.; Pretzel, David; Czaplewska, Justyna; Vitz, Jürgen; Sungur, Pelin; Höppener, Stephanie; Schubert, Stephanie; Schacher, Felix H.; Schubert, Ulrich S.; Gottschaldt, Michael

Abstract:

This paper presents the synthesis and characterization of d‐fructose modified poly(ethylene glycol) (Fru‐PEG) and fructose modified poly(ethylene glycol)‐block‐poly(ethyl hexyl glycidyl ether) (Fru‐PEG‐b‐PEHG) that are both prepared by initiation with isopropyliden protected fructose, followed by deprotection of the sugar. The block copolymers are self‐assembled into micelles, and are subsequently characterized by cryo‐TEM and dynamic light scattering. The fluorescent dye Nile red is encapsulated as a model hydrophobic compound and fluorescent marker to perform initial uptake tests with breast cancer cells. The uptake of sugar and nonsugar decorated micelles is compared.

Research areas:

• Polymer Science

Year:

2018

Type of Publication:

Article

Journal:

Macromolecular Bioscience

Volume:

18

Pages:

-

DOI:

10.1002/mabi.201700396