Biotechnology

Members

Description

The focus of our work is the understanding, characterization and optimization of polymeric materials for biological applications. We are working at the interface between macromolecular science, biology, biotechnology and nanomedicine. As an example, we investigate polymers to deliver drugs, tracer, or genetic material to cells. We further develop targeting strategies for nanomedical applications.

Confocal microscopy - ELYRA PS.1 with LSM 880

Confocal microscopy supports sensitivity demanding applications in life sciences as well as topographic tasks on materials surfaces or even particles. The complexity of experiments in biomedical research requires a deep inside into biological systems, where superresolution imaging will work best if you can image a whole cell while switching between different imaging methods in the course of an experiment. The ELYRA PS.1 provides two superresolution systems: (i) superresolution structured illumination (SR-SIM) to image fine structural details while remaining free to label your samples with conventional dyes; and (ii) superresolution photoactivated localization microscopy (PALM) for photo-activatable endogenously-expressed fluorescent proteins or synthetic dyes.

Publications

• 3rd Generation Poly(ethylene imine)s for Gene Delivery
• Local phytochemical response of Musa acuminata × balbisiana Colla cv. ‘Bluggoe’ (ABB) to colonization by Sternorrhyncha
• Synthesis and in vitro Toxicity of D -Glucose and D -Fructose Conjugated Curcumin–Ruthenium Complexes
• Antibacterial effect of silver (I) carbohydrate complexes on oral pathogenic key species in vitro
• Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity